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How do these drugs work? These drugs help your pancreas make more insulin right after meals, which lowers your blood sugar level. How do I take these drugs? Most people take these drugs in the half-hour or so before a meal. Your doctor or pharmacist will tell you how often to take it. What should I know about these drugs? Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking these medications. The common side effects include: back pain, constipation, diarrhea, headache, heart burn, joint pain, low blood sugar, nasal soreness, nausea and vomiting. Some less common and rare side effects may include: allergic reactions, angina chest pain ; , and tooth problems. Drug Interactions: If these medications are taken with certain other drugs, the effects of either could be increased, decreased, or changed. It is especially important to check with your doctor or pharmacist before combining these medications with the following: airway-opening drugs such as Prkventil , beta blockers such as the blood pressure medications Inderal and Tenormin calcium channel blockers heart and blood pressure medications such as Cardizem and Procardia ; , carbamazepine Tegretol ; , erythromycin Eryc, Ery-Tab, PCE ; , estrogens such as Premarin, major tranquilizers such as Compazine and Mellaril, birth control pills, nonsteroidal anti-inflammatory drugs such as Advil, Motrin, thyroid medications such as Synthroid and Thyrolar and water pills diuretics ; such as HydroDIURIL, Enduron, Moduretic Pregnancy: The effects of these medications during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, tell your doctor immediately. He may switch you to insulin during your pregnancy, since normal blood sugar levels are very important for the developing baby. It is not known whether these medications appears in breast milk. For safety's sake, consult with your doctor or pharmacist on whether to take these medications while breastfeeding. 14. Basco LK et al. Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the combination against uncomplicated Plasmodium falciparum malaria in young children in Cameroon. Bulletin of the World Health Organization, 2002, 80: 538545. Sowunmi A. A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology, 2002, 96: 227238. Rwagacondo CE et al. Efficacy of amodiaquine alone and combined with sulfadoxine-pyrimethamine and of sulfadoxine pyrimethamine combined with artesunate. American Journal of Tropical Medicine and Hygiene, 2003, 68: 743747. van Vugt MV et al. Efficacy of six doses of artemether-lumefantrine benflumetol ; in multidrug-resistant Plasmodium falciparum malaria. American Journal of Tropical Medicine and Hygiene, 1999, 60: 936942. Omari AA, Gamble C, Garner P. Artemether-lumefantrine for treating uncomplicated falciparum malaria. In: The Cochrane Library, Issue 4, 2004. Chichester, John Wiley & Sons search date 2004, primary sources Cochrane Infectious Diseases Group trials register, the Cochrane Controlled Trials Register, Medline, Embase, Science Citation Index, African Index Medicus and Lilacs, plus contact with experts in the field and pharmaceutical manufacturers ; . 19. Lefevre G et al. A clinical and pharmacokinetic trial of six doses of artemetherlumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand. American Journal of Tropical Medicine and Hygiene, 2001, 64: 247256. Ndayiragije A et al. Efficacit de combinaisons thrapeutiques avec les drivs de l'artmisinine dans le traitement de l'accs palustre non-compliqu au Burundi. [Efficacy of therapeutic combinations with artemisinin derivatives in the treatment of non complicated malaria in Burundi.] Tropical Medicine and International Health, 2004, 9: 673679.
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Inhaled corticosteroids are the most effective anti-inflammatory therapy available for providing long-termcontrol of asthma symptoms. The National Asthma Education and Prevention Program guidelines recommend the use of inhaled corticosteroids in all asthma patients who have symptoms more than twice a week. Because this includes most of the patients with asthma who come to a physician for asthma treatment, it is important that these medications are effective and safe and importantly, are as easy to use for the patient as possible. Fluticasone and budesonide are two inhaled corticosteroids that have become recently available. Both drugs have advantages over previously available inhaled corticosteroids including enhanced potency with fluticasone, fewer inhalations per day required for dosing, and availability as dry powder inhalers DPI ; Flovent Rotadisk and Pulmicort Turbuhaler ; . DPIs may be easier for some patients to use compared with the coordination required to effectively use a metered-dose inhaler MDI ; . Dry powder inhalers are being developed primarily because chlorofluorcarbons, which deplete the ozone layer, are being phased out of production. All metered-dose inhalers currently available except Pr0ventil HFA ; use chloroflurocarbons as the propellant.

Ome patients don't want to change from their albuterol CFC inhalers to the newer HFA versions. CFC albuterol inhalers will be gone by the end of 2008. Some people are complaining that newer versions.ProAir HFA, Ventolin HFA, and Proventiil HFA.don't work as well. Tell patients that even though HFA inhalers may not "feel" like they are working as well, they are. Explain that the softer spray still delivers the correct amount of drug. Wash the actuator with warm water once a week. This is important to prevent clogging and allow the proper dose to be delivered!

ATTENTION: Volunteers needed for Professional Word Processing30th Anniversary Celebration of t Typing Service personalized lete rs , Stony Brook May 1, 1988 ; . Inquire t e rm proposals, reports, resumes, papers, manuscripts, theses. Foreign Student Office. in 698-822-. -I Never Tdcd Anyone author Ellen Bass may 9th 8 p.m. Student Union Perfect Product Wordprocessing G iv e Raper the Professional sponsored by Campus NOW. New Deserves. Reasonable book: Courage to Heal will auto- finish it Fe e Deadlines Met. Phone 667graph. Available Barnes and Noble. 2859 for further information. Find out what's going on, call the Voice of Student Activities at 632- PCS Enterprises: typing servicereports, resumes, letters, medical 6821. Messages updated daily. reports, labels, mailing services. P CS Enterprises: 331-4460. Leave message. SERVICES and prednisolone. 1. 2. American Heart Association. Heart Attack and Angina Statistics. Available at: : americanheart presenter.jhtml?identifier 4591. Accessed March 9, 2006. Gibbons RJ, Abrams J, Chatterjee K, et al. American College of Cardiology; American Heart Association Task Force on practice guidelines Committee on the Management of Patients With Chronic Stable Angina ; . ACC AHA 2002 guideline update for the management of patients with chronic stable angina: A report of the American College of Cardiology American Heart Association Task Force on practice guidelines Committee on the Management of Patients with Chronic Stable Angina ; . Available at: : acc clinical guidelines stable stable clean . Accessed February 18, 2006. Crawford M. Chronic Ischemic Heart Disease In: Crawford M ed ; . Current Diagnosis & Treatment in Cardiology, 2nd ed. New York: Lange Medical Books McGraw-Hill; 2003: Available at: : online atref document x?fxid 19&docid 24. Accessed March 9, 2006. Shah P, Chyu K. Unstable Angina. In: Crawford M ed ; . Current Diagnosis & Treatment in Cardiology, 2nd ed. New York: Lange Medical Books McGraw-Hill; 2003: Available at: : online atref document x?fxid 19&docid 29. Accessed March 9, 2006. Canadian Cardiovascular Society. Grading of Angina. Available at: : ccs download position statements Grading%20of%20Angina . Accessed March 9, 2006. Gibbons RJ, Abrams J, Chatterjee K, et al. American College of Cardiology; American Heart Association 2002 guideline update for the management of patients with unstable angina and non-STsegment elevation myocardial infarction--summary article: a report of the American College of Cardiology American Heart Association task force on practice guidelines Committee on the Management of Patients With Unstable Angina ; . Available at: : acc clinical guidelines unstable unstable . Accessed February 18, 2006. European Society of Cardiology. Management of stable angina pectoris. Recommendations of the Task Force of the European Society of Cardiology. Eur Heart J. 1997 Mar; 18 3 ; : 394-413. Bertrand ME, Simoons ml, Fox KA, et al. Task Force on the Management of Acute Coronary Syndromes of the European Society of Cardiology. Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2002; 23 ; : 1809-40. Snow V, Barry P, Fihn SD, et al. American College of Physicians; American College of Cardiology Chronic Stable Angina Panel. Primary care management of chronic stable angina and asymptomatic suspected or known coronary artery disease: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2004; 141 7 ; : 562-7. Moms will have many questions about breastfeeding. Read through "Commonly Asked Questions" in the Breastfeeding Education Guide, pages 80-83. Answer the following questions using the Breastfeeding Education Guide, "Breastfeeding Challenges Solutions, " pages 84-117. A mom tells you that her baby is refusing to nurse. What are some of the possible causes? Possible causes located on pages 88-92 of the Breastfeeding Education Guide and prednisone. As stated in the January 2003 issue of Pearls, this condition is extremely debilitating and is often resistant to all forms of treatment. Surprisingly, calcitonin nasal spray has been found useful in reducing pain in these patients and is considered a first line drug in some countries. I not sure at which point in time calcitonin nasal spray is no longer effective; however, as it is so free from side effects, it would seem logical to attempt a 1-2 month trial of this spray if it has not been tried previously.

Products manufactured by this brand name manufacturer in this drug entity are available for drug product selection under other brand and or generic names. * Provenyil and Ventolin brands of albuterol metered dose inhalers are NOT INTERCHANGEABLE at this time. Neither company has to date presented acceptable bioequivalence information comparing their brand of albuterol metered dose inhaler to the other. Schering, via Warrick Pharmaceuticals, is manufacturing a generically labeled albuterol metered dose inhaler using the Provebtil federal new drug application NDA ; while GlaxoSmithKline is doing the same, manufacturing an "authorized generic" for distribution under generic labeling by Dey Laboratories, using the Ventolin NDA. Thus, Schering manufactured generically labeled albuterol metered dose inhalers are NOT INTERCHANGEABLE with GlaxoSmithKline manufactured generically labeled albuterol metered dose inhalers. * Albuterol metered dose inhalers manufactured by Armstrong formerly Celltech or Medeva ; , GenPharm formerly Alpharma ; , Sidmak formerly Medisol ; , and IVAX formerly Norton Waterford ; are, at this time, only interchangeable with albuterol metered dose inhalers manufactured by GlaxoSmithKline and ventolin. Investment climate strategy to maintain its emphasis on education and broadening of available skills, and to attain a uniformly high level of efficiency with regard to its capacity to support regional trade. Namibia is ranked 43 on the Global Competitiveness Index of 104 countries 2004 ; . External investors are principally drawn to Namibia for its natural assets for example, mining and fisheries resources and its geographic location ; . With respect to value-added products, Namibia's immediate southern neighbor, South Africa offers considerable competition as a continental, as well as regional, industrializing engine with a much larger economy, inclusive of production of a much greater number and range of product lines. Therefore, Namibia must work hard to identify "niche" product lines that can compete regionally principally, at this time, with South Africa ; and or continentally globally. Until the regional market is more developed, Namibia's major markets will likely continue to be large foreign markets for example via regional, EU, AGOA and other trading blocks ; . The economy is transforming from a purely natural-resource based economy to a more diversified economy with some processing of natural materials for example diamonds and marble ; and other value added activities for example textiles ; , a stronger contribution of the services sector, notably the tourism and financial service sectors, and emerging diversification into on-land marine and freshwater fish farming, exploitation of indigenous natural plants and fruits, and high value irrigation production for example grapes and dates ; . Some charts relating trends in composition of GDP and exports below illustrate this Figures 1.1 and 1.2.

However, if we assume that all cox-2 inhibitors have the same stroke risks based on the medal results ; , then etoricoxib 30 mg would be the most cost effective of the included drugs table 20 and flonase. 4.74 Regionaldifferencesin health expenditures. Health reforms seem to have decreased regional differences in access to publicly financed care. Hospital coverage in SUS-affiliated facilitieswas more homogeneousin 1992 than in 1990, mostly because coverage expandedin poorer Northeastern states like Alagoas, Ceara and Pernambuco. Interestingly, in 1992 the number of SUS hospital stays per 100 inhabitantswas slightly higher in the Northeast than in the Southeast. However, the total value of SUS hospital reimbursementswas higher in the Southeastbecause of greater costs per hospital stay in this region. 4.75 Despitethese improvements, the data suggestthe persistenceof gaps in the coverageand quality of publicly financed care between the richer and poorer macroregions. In 1992 governmentoutlays per hospital stay were 23% higher in the Southeast than in the Northeast. Similarly, in 1993the averagenumber of per capita out-patientmedicalconsultationsin the SUS systemwas 1.3 states in the Northeast, whereas states located in the Southeastaveraged 2.3 for medicalconsultationsper inhabitant. 4.76 lTrends since 1990. In the early 1990s, federal spendingon health declinedsharply. In 1990 federal health expenditureswere .1 billion per capita ; . By 1992 sectoral outlays had dropped to .7 billion per capita ; . Federal funding for health was adverselyaffected not only by the economic crisis, but also by the health sector's need to compete with social insurance for the same funds. As noted above, the Constitutionof 1988 stipulated that social insuranceand healthcare would share the samefundingsources. Healthspendingsuffered much larger cutbacks than social insurance both in absolute amounts and relative terms during the.

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Understanding Your Medication Your doctor may have prescribed one or more medications to help you manage your COPD. Sometimes you may be instructed to take more than one medication because the medicines work together to help control your symptoms. For example, medicines, when taken as part of the treatment plan from your doctor, can: reduce your symptoms such as shortness of breath, enable you to exercise more, be more active and do more things you like to do, help to prevent potential flare-ups from occurring There are medicines that, when taken, open up the airways in your lungs by relaxing the muscle around the airways. These are called bronchodilators and some of them work quickly and others work over 12 or even 24 hours. There are other medications that work to treat the inflammation swelling ; inside the airways in your lungs. These are called corticosteroids. The chart below outlines the most commonly prescribed medicines used to treat COPD and what the medicines do for your lungs. Medications Commonly Used for the Treatment of COPD Medication Name Albuterol Proventil and Ventolin ; Atrovent or Ipatropium generic ; Spiriva Serevent Drug Type Fast Acting Bronchodilator Fast Acting Bronchodilator Long Acting Bronchodilator Long Acting Bronchodilator Important Information Fast acting: use this to relieve symptoms quickly by helping to open the airways. Fast acting: this also helps to open up your airways quickly Works for 24 hours to help you breathe better by keeping your airways open. Works for 12 hours. Not recommended to treat an asthma attack that has already begun. It will not work fast enough to reverse your symptoms. Serevent is used as a preventive to keep your airways open. Take as prescribed by your physician. Works for 12 hours. Not recommended to treat an asthma attack that has already begun. It will not work fast enough to reverse your symptoms. Foradil is used as a preventive to keep your airways open. Take as prescribed by your doctor. Combination of albuterol and atrovent. Fast acting medicine to help open your airways to help you breathe better. Works for 4-6 hours. Helps to keep your airways open, and decrease any swelling you may have, to help you breathe better. Remember to rinse out your mouth afterwards to prevent thrush. Clinical rheumatologists should be tolerating less and less disease activity because we have agents available that, when used skillfully and judiciously in combination, can get our patients to a much better quality of life with less disease progression and less disability, " asserted Dr. Kremer. "For the most part, we know the issues associated with the use of these agents. It does take time, effort, and energy to monitor these drugs and to educate our patients about potential risk factors. But I think there are significant returns to be gained in terms of satisfaction and improvement in the overall status of our patients with this disease." "From the practices of our colleagues and our own experiences, it is clear that combination therapy is the cornerstone of treatment in rheumatoid arthritis, " declared Dr. Cush in formulating his final take-away message. "The success of combination therapy in a complex disease like rheumatoid arthritis provides further evidence that, as we go forward pursuing new advances in our understanding of the disease and new developments in therapies to treat the disease, we must focus on the most pivotal mechanisms to successfully dismantle it. The success of combination and rhinocort.

Bipolar Disorder I one or more manic or mixed episodes, possibly one or more major depressive episodes Bipolar Disorder II one or more major depressive episodes in conjunction with at least one hypomanic episode Mood Disorder-Cyclothymia Periods of hypomania with periods of depression for at least two years. Depressive states do not include symptoms of major depressive disorder. Major Depressive Episode Criteria lasting over at least a two week period ; Three to four of the following symptoms that impair functioning Depressed mood on most days Decreased pleasure or interest in activities Significant weight loss or weight gain without trying ; Insomnia or somnolence almost every day Erratic or slowed muscle movements Fatigue or loss of energy Inability to concentrate or make decisions Feeling worthless Thoughts of death, suicidal ideation, suicide attempts Manic Episode Criteria A period of elevated, expansive, or irritable mood, lasting at least 1 week or requiring hospitalization ; Three to four of the following symptoms persist and impair functioning Inflated self-esteem, grandiose feelings Diminished desire for sleep Need to talk more Racing thoughts More goal directed Easily distracted, agitated physically and mentally ; Engaging in pleasurable activities that have negative outcomes Hypomanic Episode Criteria Same as Manic Episode criteria but do not impair functioning but are observable by others ; Mixed State.

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Medication for a short duration, up to a 30-day supply, may be obtained from a Participating Pharmacy by using your PERS Choice Supplemental Plan ID card. While this program was designed primarily for use in California, there are many Participating Pharmacies outside California that will also accept your PERS Choice Supplemental Plan ID card. At Participating Pharmacies, simply show your ID card and pay either a five dollar .00 ; copayment for generic medications, a fifteen dollar .00 ; copayment for Preferred brand-name medications, or a forty-five dollar .00 ; copayment for Non-Preferred brand-name medications. Non-Preferred brand-name medications can be purchased for a thirty dollar .00 ; copayment with an approved partial copayment waiver pages 39 and 40 ; . If the pharmacy does not accept your ID card and is a Non-Participating Pharmacy defined on page 46 ; , there is additional cost to you. If you refill a maintenance medication at a retail pharmacy after the second fill, you will be charged a higher copayment, which is the applicable mail-order copayment described above under Copayment Structure and serevent.

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Brand Name Oral Proventil Repetab Volmax Inhaled Serevent Foradil Aerolizer Generic Name Albuterol Things to Know Relaxes muscles to open airways Works in 1 hour, and lasts 9-12 hours Never use to relieve symptoms Possible Side Effects Shaky hands, "hyper" feeling, fast heartbeat, headache Side effects usually last only a short time, and will probably go away after using the medicine regularly. Call the doctor if side effects are too bothersome or do not go away. Although PTSD is common after combat exposure, serious accidents represent a leading cause in the general population 548550 ; , with an estimated 9% of accident victims developing PTSD 542 ; . Other potential PTSD patients include victims of physical attack, rape, sexual abuse, violent crimes, accidents, terrorist attacks, or natural disasters 542, 549551 ; . In Canada, the most common forms of trauma resulting in PTSD include unexpected death of a loved one, sexual assault, and seeing someone badly injured or killed 540 ; . Caregivers of trauma victims 552554 ; and parents of children who die violent deaths 555, 556 ; may also present with PTSD symptoms. PTSD is frequently comorbid with other psychiatric disorders, including other anxiety disorders SAD, OCD, and panic disorder ; , MDD, personality disorders, and substance abuse disorders, which may further complicate diagnosis and management 550, 557, 558 ; . It is important to ask all patients with mental health symptoms about trauma, particularly women suffering from treatment-resistant depression 559 ; and those with general medical complaints, since patients with PTSD often present with somatic symptoms. Most individuals exposed to a traumatic event do not develop a psychiatric illness. In addition, PTSD is just one of the possible psychiatric outcomes of exposure to traumatic events; other outcomes include other anxiety disorders, depression, substance abuse disorders, and a range of other problems and astelin.
Special situations High-risk preterm labor when delivery is imminent Rapidly infuse 1000 ml of NR via IV. Administer Albuterol Sulfate Proventil ; - 2.5 mg via nebulization. Significant hemorrhage following delivery or delayed placenta delivery Unless multiple births are anticipated, begin fundal massage Refer to Resuscitation and Perfusion Core Principle Nuchal cord Attempt to slip cord over the head If cord is too tight to remove, immediately clamp in two places and cut between clamps Prolapsed cord or limb presentation With maintaining a pulsatile cord as the objective, two fingers of gloved hand into vagina to raise presenting portion of newborn off the cord. If possible, place mother in Trendelenburg position. Otherwise, knee-chest. Keep cord moistened with sterile saline. From left to right: William T. McKee, Senior Vice President and Chief Financial Officer; Dr. Carole S. BenMaimon, President and Chief Operating Officer of Barr Research; Mr. Downey; and Paul M. Bisaro, President and Chief Operating Officer, Barr Laboratories and allegra and Proventil online. This REQUIREMENT is not met as evidenced by: Based on observation, medical record review, and staff interviews, it was determined that for 4 of 40 medication administration opportunities observed, the facility did not maintain a medication error rate of less than five percent. The issue was related to administration of inhalents and bronchodilators without sufficient time intervals between puffs, resulting in a medicaton error rate of 10 percent. This resulted in no actual harm with potential for more than minimal harm that is not immediate jeopardy for Residents #1, #30, #33, and #34, and is evidenced by, but not limited to, the following.

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Table V. Coefficients appropriate for determining approximate relative standard errors by type of estimate and physician specialty: National Ambulatory Medical Care Survey, 2000 reliable Type of estimate Coefficient for use estimate and physician specialty with estimates in thousands in thousands ; A B Overall totals . General and family practice. Internal medicine . Pediatrics . General surgery . Obstetrics and gynecology . Orthopedic surgery. Cardiovascular diseases . Dermatology. Urology . Psychiatry . Neurology . Ophthalmology . Otolaryngology . All other specialties . Drug mentions Overall totals . 0.005585 186.323 2, General and family practice . 0.017526 198.381 2, Internal medicine . 0.018944 201.993 2, Pediatrics . 0.014322 94.135 1, General surgery . 0.042731 52.401 1, Obstetrics and gynecology . 0.018138 174.742 2, Orthopedic surgery. 0.013282 61.736 805 Cardiovascular diseases . 0.021379 83.955 1, Dermatology. 0.013943 46.197 608 Urology . 0.018820 25.639 361 Psychiatry . 0.023188 139.797 2, Neurology . 0.013979 23.189 306 Ophthalmology . 0.020464 124.722 1, Otolaryngology . 0.016904 21.887 300 All other specialties . 0.031762 556.815 9, These coefficients apply to NAMCS data where doctors of osteopathy D.O.'s ; have been aggregated with doctors of medicine M.D.'s ; according to their self-designated practice specialty. For those who wish to conduct a separate analysis on visits to doctors of osteopathy, the A and B coefficients for use with visit estimates in thousands are 0.017822 and 52.790, respectively. The corresponding coefficients for estimates of drug mentions in thousands are 0.024949 and 95.635. To perform analyses of NAMCS data on visits to M.D.'s only, excluding doctors of osteopathy, contact the Ambulatory Care Statistics Branch. 0.012743 0.017249 0.010667 and aristocort. Unless otherwise noted on the Formulary Exclusions List, all generically available covered oral products available by prescription are on Aetna's Preferred Drug List. Where appropriate, please consider prescribing generic products first. Sulfonamides all generics Tetracyclines all generics PR 8 yr old Miscellaneous Dapsone Mepron Nebupent Zyvox PR Musculoskeletal System Gout all generics Muscle Relaxants Antispasmodics Skelaxin Muscle Stimulants Mestinon NSAIDs all generics except for those noted on the Formulary Exclusions list Osteoporosis Paget's Disease Actonel QL Evista Forteo SI Fosamax QL Rheumatoid Arthritis all generics Nose Astelin Flonase Nasonex Respiratory System Antihistamines Decongestants all generics Asthma Advair Diskus Flovent Flovent Rotadisk Foradil Maxair Autohaler Proventil HFA Pulmicort Respules only Serevent Diskus Singulair Uniphyl COPD -- Inhaled Combivent inhaler Duoneb Foradil Serevent Diskus Cough -- Narcotic Tussionex susp Cough -- Non-Narcotic all generics Miscellaneous Epipen Epipen Jr Pulmozyme Throat and Mouth Evoxac Vitamins, Minerals and Salts Fluoride all generics. Supervisory visits to the outbreak site by the national or peripheral EpiNet team is imperative during an outbreak. If health facilities are not submitting reports, visits to these sites to determine if cases are occurring should be considered. Developments During 2006 Dacogen for Injection "Dacogen" ; : We received approval from the FDA for Dacogen for the treatment of patients with MDS on May 2, 2006. In August 2006, the FDA and the European Medicines Agency "EMEA" ; granted Dacogen orphan drug designation for the Aml indication. On July 6, 2006, we entered into a license agreement with Cilag GmbH "Cilag" ; , a Johnson & Johnson company, granting exclusive development and commercialization rights for Dacogen in all territories outside North America to Janssen-Cilag companies, members of the Johnson & Johnson family of companies. Pursuant to the terms of this agreement, we received from Cilag an upfront payment of million and may earn milestone payments totaling more than million should all specified clinical development, regulatory, and commercial goals be achieved. Under the terms of the Dacogen license agreement between us and SuperGen, Inc. "SuperGen" ; , we will share these upfront and milestone payments from Cilag with SuperGen. In addition to the previously described payments, in the three years from the date of the agreement, we will receive from Cilag research and development support totaling million related to specified clinical development activities. We and Cilag will jointly implement a strategic plan for the global clinical development of Dacogen. Under the terms of this agreement, we will retain all commercialization rights to Dacogen in North America. Janssen-Cilag companies will be responsible for conducting regulatory and commercial activities related to Dacogen in all territories outside North America, while we retain responsibility for all activities in the United States, Canada and Mexico. 3.

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